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• Adopting mechanistic molecular biology approaches in exposome research for causal understanding: a call for action.
• Age at onset as stratifier in idiopathic Parkinson's disease – effect of ageing and polygenic risk score on clinical phenotypes
• Alpha-synuclein pathology is associated with astrocyte senescence in Parkinson’s disease patient-specific midbrain organoids
• Alpha-synuclein pathology transfer in a midbrain-hindbrain assembloid model
• An explorable model of an adverse outcome pathway of cytokine release syndrome related to the administration of immunomodulatory biotherapeutics and cellular therapies
• Atlas of metabolism regulation diagrams: post-translational modification of enzymes
• Beyond FAIR: Reusing Chemical Data Across Disciplines
• Beyond target chemicals: Updating the NORMAN Prioritization Scheme to Support the EU Chemical Strategy with Semi-quantitative Suspect/Non-target screening data
• Biflavonoid methylchamaejasmin and Khaya grandifoliola extract inhibit inflammasome in THP-1 cells model of neuroinflammation
• Bioinformatics approaches to study molecular sex differences in complex diseases
• Body-first subtype of Parkinson's disease with probable REM-sleep behaviour disorder is associated with non-motor dominant phenotype
• Bridging the gap between visual assessments and self-reported outcomes for optimal mobility modeling in Geriatrics.
• Building an international and interdisciplinary community to develop immune digital twins for complex human pathologies
• CALIFRAME: A Proposed Method of Calibrating Reporting Guidelines with FAIR Principles to Foster Reproducibility of AI Research in Medicine
• COBREXA 2: tidy and scalable construction of complex metabolic models
• COBREXA.jl: constraint-based reconstruction and exascale analysis
• Can Small Molecules Provide Clues on Disease Progression in Cerebrospinal Fluid from Mild Cognitive Impairment and Alzheimer’s Disease Patients?
• ChemPert: mapping between chemical perturbation and transcriptional response for noncancer cells
• Clustering and visualizing huge-scale cytometry datasets with GigaSOM.jl
• Cognitive capacity in amyotrophic lateral sclerosis: The value of diagnostic markers in cerebrospinal fluid and the influence of nutrition and pulmonary function
• Cohort-specific Boolean models highlight different regulatory modules during Parkinson’s disease progression
• Comprehensive Characterization of European House Dust Contaminants: Contaminant Concentrations and Profiles, Geographical Variability, and Implications for Chemical Regulation and Health Risk
• Comprehensive mass spectrometry workflows to systematically elucidate transformation 1 processes of organic micropollutants: a case study on photodegradation of four pharmaceuticals
• Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses
• Concomitant AD and DLB pathologies shape subfield microglia responses in the hippocampus
• Converging Peripheral Blood MicroRNA Profiles in Idiopathic Parkinson’s Disease and Progressive Supranuclear Palsy
• DS-PACK: Tool assembly for the end-to-end support of controlled access human data sharing
• Dibac: Distribution-Based Analysis Of Cell Differentiation Identifies Mechanisms Of Cell Fate
• Dopamine-iron homeostasis interaction rescues mitochondrial fitness in Parkinson’s disease
• ENA Dataset for Systematic characterization of human gut microbiome-secreted molecules by integrated multi-omics study
• Education as risk factor of mild cognitive impairment: the link to the gut microbiome
• Evaluation of Quantitative Approaches in Non-Target LC/ESI/HRMS Analysis
• Exome Sequencing of Consanguineous Pashtun Families With Familial Epilepsy Reveals Causative and Candidate Variants in TSEN54, MOCS2, and OPHN1
• Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes
• Exploring Adult Glioma through Magnetic Resonance Imaging: A Global Review of Publicly Available Datasets
• Exploring Environmental Modifiers of LRRK2-Associated Parkinson’s Disease Penetrance through Exposomics and Metagenomics in Household Dust
• Exposomics Education: Lessons from the Exposome Bootcamp
• FAIR assessment as an opportunity to foster open science and scientific crowdsourcing in systems biomedicine: the example of the COVID-19 Disease Map
• FROG Analysis Ensures the Reproducibility of Genome Scale Metabolic Models
• Failure to repair damaged NAD(P)H blocks de novo serine synthesis in human cells
• Federated Electronic Health Records for the European Health Data Space: An architecture proposal to break the privacy-exploitation barrier
• Functional meta-omics provide critical insights into long and short read assemblies
• Gene regulatory network inference from single-cell data using optimal transport
• Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.1290A>G (p.T351A) or c.2067A>G (p.T610A) in the RHOT1 gene encoding Miro1
• Generation of two induced pluripotent stem cell lines and the corresponding isogenic controls from Parkinson’s disease patients carrying the heterozygous mutations c.815G>A (p.R272Q) or c.1348C>T (p.R450C) in the RHOT1 gene encoding Miro1
• Genetic landscape of Parkinson’s disease in Luxembourg
• Genetically stratified Parkinson’s disease with freezing of gait is related to specific pattern of cognitive impairment and non-motor dominant endophenotype
• Genome-wide association study of copy number variations in Parkinson's disease
• Genomics 2 Proteins portal: a resource and discovery tool for linking genetic screening outputs to protein sequences and structures
• Getting ready for the European Health Data Space (EHDS): the IDERHA’s plan to align with the EHDS requirements for the secondary use of health data
• Grouping strategies for assessing and managing persistent and mobile substances
• Guidelines and Standard Frameworks for Artificial Intelligence in Medicine: A Systematic Review
• Harmonized quality assurance/quality control provisions to assess completeness and robustness of MS1 data preprocessing for LC-HRMS-based suspect screening and non-targeted analysis
• IMP: a pipeline for reproducible reference-independent integrated metagenomic and metatranscriptomic analyses
• Ice Recrystallization Inhibitors enable efficient cryopreservation of induced pluripotent stem cells: A functional and transcriptomic analysis
• Identifiability of Differential-Algebraic Systems
• Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR
• Impaired dopaminergic neuronal differentiation in GBA associated Parkinson’s disease midbrain organoids is accompanied by an increased progenitor pool in cell cycle arrest
• InChI Isotopologue and Isotopomer Specifications
• Insulin resistance compromises midbrain organoid neural activity and metabolic efficiency predisposing to Parkinson’s disease pathology
• Insulin resistance is a modifying factor for Parkinson's disease
• Integrated multi-omics highlights alterations of gut microbiome functions in prodromal and idiopathic Parkinson’s disease
• Integrating digital gait sensor data with metabolomics and clinical data to predict clinically relevant outcomes in Parkinson’s disease
• Interpretable Machine Learning Models for Motor Fluctuations in Parkinson’s Disease with Cross-Cohort Analysis
• Levodopa-induced Dyskinesia in Parkinson's Disease: Insights from cross-cohort prognostic analysis using machine learning
• Luxembourg Parkinson's study - comprehensive baseline analysis of Parkinson's disease and atypical parkinsonism
• MIRO1 mutation leads to metabolic maladaptation resulting in Parkinson’s disease-associated dopaminergic neuron loss
• MaBoSS for HPC environments: Implementations of the continuous time Boolean model simulator for large CPU clusters and GPU accelerators
• Machine learning-assisted neurotoxicity prediction in human midbrain organoids
• Meta-analysis of gender-dependent gene expression alterations in Parkinson's disease
• Metabolite identification in metabolic phenotyping
• Metadata for the RESOLUTE project in the IMI Data Catalog
• Method optimization of skin biopsy-derived fibroblast culture for reprogramming into induced pluripotent stem cells (iPSCs)
• Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality
• Midbrain organoids mimic early embryonic neurodevelopment and recapitulate LRRK2-G2019S - associated gene expression
• Mild cognitive impairment in Parkinson’s disease is not associated with specific microbial community changes
• Mitochondrial morphology provides a mechanism for energy buffering at synapses
• Modeling Parkinson's disease in midbrain-like organoids
• Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids
• Morphological profiling in human dopaminergic neurons identifies mitochondrial uncoupling as a neuroprotective effect
• Multi-cohort Machine Learning Approach Identifies Robust Predictors of Cognitive Impairment in Parkinson's Disease
• Multi-omic network inference from time-series data
• Multidimensional Library for the Improved Identification of Per- and Polyfluoroalkyl Substances (PFAS)
• NLRP3-mediated glutaminolysis regulates microglia in Alzheimer’s disease
• NORMAN Guidance on Suspect and Non-Target Screening in Environmental Monitoring
• New Assessment of Digital Medical Devices (DMDs): A roadmap towards harmonised evidence-based digital medicine in Europe
• Non-Target Screening of Surface Water Samples to Identify Exposome-Related Pollutants: A Case Study from Luxembourg
• Objective Monitoring of Motor Symptoms and their Progression in Parkinson’s Disease Using a Digital Gait Sensor
• Omics data integration suggests a potential idiopathic Parkinson’s disease signature
• PRECISESADS: Molecular reclassification to find clinically useful biomarkers for systemic autoimmune diseases
• PaFSe: a Parameter Free Segmentation Approach for 3D Fluorescent Images
• Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐Cyclodextrin Treatment
• Parkinson's disease mutant Miro1 causes mitochondrial dysfunction and dopaminergic neuron loss
• Passive controlled flow for neuronal cell culture in 3D microfluidic devices
• Patient empowerment as capabilities for people with chronic condition supported by digital health technologies: a scoping review
• Patient perspectives on the use of digital medical devices and sensitive health data for AI-driven personalized medicine in Parkinson
• Penalised regression with multiple sources of prior effects
• Per- and polyfluoroalkyl substances (PFAS) in PubChem: 7 million and growing
• Polarization of multi-agent gradient flows over manifolds with application to opinion dynamics
• Predictive Models for Health Deterioration: Understanding Disease Pathways for Personalized Medicine
• Privacy Policy
• Programme Dementia Prevention (pdp): A Nationwide Program for Personalized Prevention in Luxembourg
• Progression Subtypes in Parkinson's Disease: An In- depth Analysis Based on Longitudinal Cohorts and Its Impact on Clinical Trial Design
• PubChemLite plus Collision Cross Section (CCS) values for enhanced interpretation of non-target environmental data
• Reproducible generation of human midbrain organoids for in vitro modeling of Parkinson's disease
• Retrograde procedural memory in Parkinson's disease: a cross-sectional, case-control study
• Retrospective Non-target Analysis to Support Regulatory Water Monitoring: From Masses of Interest to Recommendations via in silico workflows
• Revealing Chemical Trends: Insights from Data-Driven Visualisation and Patent Analysis in Exposomics Research
• SMASCH: multi-appointment scheduling system for longitudinal clinical research studies
• Seizure-induced increase in microglial cell population in the developing zebrafish brain
• Sex-Dependent Alterations of Apoptotic Processes in Alzheimer's Disease Revealed by Large-Scale Single-Cell Transcriptomics
• Should transformation products change the way we manage chemicals?
• SinCMat : A single-cell based method for predicting maturation transcription factors
• Single cell transcriptome analysis of the THY-Tau22 mouse model of Alzheimer's disease reveals sex-dependent dysregulations
• Single cell transcriptomics of human iPSC differentiation dynamics reveal a core network of Parkinson’s disease
• Single-Cell Comparative Analysis of Early-Stage Alzheimer's and Parkinson's Disease-Related Changes in Brain Organoid Models
• Single-Cell Cortical Transcriptomics Reveals Common and Distinct Pathway Activity Signatures in Alzheimer’s and Parkinson’s Disease
• Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids
• Socio-ethical challenges and opportunities to advance diversity, equity, and inclusion in digital medicine: Narrative Review
• Structural basis of the transhydrogenase and allosteric regulation mechanisms of Ser33, the first rate‐limiting enzyme of the de novo L-serine biosynthesis pathway
• Synapse alterations precede neuronal damage and storage pathology in a human cerebral organoid model of CLN3-juvenile neuronal ceroid lipofuscinosis
• Synaptic decline precedes dopaminergic neuronal loss in human midbrain organoids harboring a triplication of the SNCA gene
• Ten Simple Rules For Successful Development And Implementation Of Digital Health Solutions
• The Parkinson's disease associated mutation LRRK2-G2019S alters dopaminergic differentiation dynamics via NR2F1
• The SYSCID map: a graphical and computational resource of molecular mechanisms across rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease
• The use of graph databases in systems biology: a systematic review
• Topological analysis of brain dynamical signals indicates signatures of seizure susceptibility
• Trans-ancestry polygenic models for the prediction of LDL blood levels: an analysis in UK Biobank and Taiwan Biobank
• Transcriptional Dysregulation in the Hippocampus of a Mouse Model for Parkinson's - Linked Cognitive Decline is Driven by Sex, Age, and Alpha-synuclein overexpression
• Uncovering Clinical Characteristics of Parkinson’s Disease Patients with Delayed Diagnosis Through Predictive Modeling
• Using High-Content Screening to Generate Single-Cell Gene-Corrected Patient-Derived iPS Clones Reveals Excess Alpha-Synuclein with Familial Parkinson’s Disease Point Mutation A30P
• Visualization of automatically combined disease maps and pathway diagrams for rare diseases
• Zebrafish models of PEBEL 1 & 2 neurometabolic disorder reveal that impairments of immune system participate in disease manifestation
• sccca: Single-Cell Correlation Based Cell Type Annotation